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HLA allele profiling and association in Thai patients with confirmed beta-lactam hypersensitivity: an NGS-based analysis

BackgroundBeta-lactams (BLs) are the most common reported antibiotics associated with hypersensitivity reactions (HSRs). However, evidence for human leukocyte antigen (HLA) associations with beta-lactam hypersensitivity reaction (BL-HSR) remains limited and population-specific, particularly in the T...

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Principais autores: Lalita Lumkul, Prapasri Kulalert, Mongkhon Sompornrattanaphan, Thanachit Krikeerati, Supharat Suvichapanich, Patcharawadee Thongkumkoon, Pitiporn Noisagul, Chamard Wongsa, Torpong Thongngarm, Wannada Laisuan, Dumnoensun Pruksakorn, Padcha Pongcharoen, Sira Nanthapisal, Ratchaya Lertnawapan, Phichayut Phinyo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-07-01
Serier:Frontiers in Pharmacology
Fag:
allergy
antibiotics
beta-lactam hypersensitivity reactions
genetic association
human leukocyte antigen
HLA
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1782094/full
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