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The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity

Summary: We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity (277 unique genes; false discovery rate < 10%). Since circulating EVs may have broad origin, we compared this obesity EV transcriptome wi...

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Principais autores: Emeli Chatterjee, Michael J. Betti, Quanhu Sheng, Phillip Lin, Margo P. Emont, Guoping Li, Kaushik Amancherla, Marta Garcia-Contreras, Priyanka Gokulnath, Worawan B. Limpitikul, Olivia Rosina Whittaker, Kathy Luong, Christopher Azzam, Denise Gee, Matthew Hutter, Karen Flanders, Parul Sahu, Charles R. Flynn, Jonathan Brown, Danxia Yu, Evan D. Rosen, Kendall Van-Keuren Jensen, Eric R. Gamazon, Ravi Shah, Saumya Das
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-09-01
Serier:Cell Genomics
Fag:
extracellular vesicles
obesity
plasma
visceral adipose tissue
BMI
RNA
Online adgang:http://www.sciencedirect.com/science/article/pii/S2666979X25001818
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