T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants

Fluorescently activated cell-sorting coupled with high-throughput single cell mtDNA sequencing reveals enhanced negative selection of pathogenic mtDNA variants in T cells, with more mature, memory cells exhibiting lower mutation levels than their naïve counterparts. Pathogenic mitochondrial DNA (mtD...

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Hlavní autoři:	Imogen G Franklin, Paul Milne, Jordan Childs, Róisín M Boggan, Isabel Barrow, Conor Lawless, Gráinne S Gorman, Yi Shiau Ng, Matthew Collin, Oliver M Russell, Sarah J Pickett
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Life Science Alliance LLC 2023-11-01
Edice:	Life Science Alliance
On-line přístup:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202302271
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