T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants
Fluorescently activated cell-sorting coupled with high-throughput single cell mtDNA sequencing reveals enhanced negative selection of pathogenic mtDNA variants in T cells, with more mature, memory cells exhibiting lower mutation levels than their naïve counterparts. Pathogenic mitochondrial DNA (mtD...
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| Автори: | , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Life Science Alliance LLC
2023-11-01
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| Серія: | Life Science Alliance |
| Онлайн доступ: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202302271 |
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