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Primary Cells from a <i>CD46</i>-Edited Bovine Heifer Have Reduced BVDV Susceptibility Despite Viral Adaptation to Heparan Sulfate

A precision genome edit in the bovine <i>CD46</i> gene (A<sub>82</sub>LPTFS<sub>87</sub>) dramatically reduced bovine viral diarrhea virus (BVDV) susceptibility in a cloned heifer. However, pathogen evolution threatens the long-term efficacy of such interventions. Here, our aim is two-fold: first, t...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Alexandria C. Krueger, Brian L. Vander Ley, Michael P. Heaton, Tad S. Sonstegard, Aspen M. Workman
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2025-04-01
Rangatū:Viruses
Ngā marau:
Urunga tuihono:https://www.mdpi.com/1999-4915/17/5/634
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