Implications of non-uniqueness in phylogenetic deconvolution of bulk DNA samples of tumors

Abstract Background Tumors exhibit extensive intra-tumor heterogeneity, the presence of groups of cellular populations with distinct sets of somatic mutations. This heterogeneity is the result of an evolutionary process, described by a phylogenetic tree. In addition to enabling clinicians to devise...

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Autors principals:	Yuanyuan Qi, Dikshant Pradhan, Mohammed El-Kebir
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-09-01
Col·lecció:	Algorithms for Molecular Biology
Matèries:	Phylogenetics Intra-tumor heterogeneity Inter-tumor heterogeneity Somatic mutations Single-nucleotide variant Copy-number aberration
Accés en línia:	http://link.springer.com/article/10.1186/s13015-019-0155-6
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