Highly Accurate Estimation of Cell Type Abundance in Bulk Tissues Based on Single‐Cell Reference and Domain Adaptive Matching

Abstract Accurately identifies the cellular composition of complex tissues, which is critical for understanding disease pathogenesis, early diagnosis, and prevention. However, current methods for deconvoluting bulk RNA sequencing (RNA‐seq) typically rely on matched single‐cell RNA sequencing (scRNA‐...

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Bibliografische gegevens

Hoofdauteurs:	Xinyang Guo, Zhaoyang Huang, Fen Ju, Chenguang Zhao, Liang Yu
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2024-02-01
Reeks:	Advanced Science
Onderwerpen:	deconvolution tissue heterogeneity transcriptomics transfer learning
Online toegang:	https://doi.org/10.1002/advs.202306329
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