Endo‐Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1‐Null Rat Hippocampus

Abstract Sortilin‐related receptor 1 (SorL1) deficiency is a genetic predisposition to familial Alzheimer’s disease (AD), but its pathology is poorly understood. In SorL1‐null rats, a disorder of the global endosome‐lysosome network (ELN) is found in hippocampal neurons. Deletion of amyloid precurso...

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Váldodahkkit:	Yajie Wang, Yuting Yang, Ying Cai, Ayikaimaier Aobulikasimu, Yuexin Wang, Chuanwei Hu, Zhikang Miao, Yue Shao, Mengna Zhao, Yue Hu, Chang Xu, Xinjun Chen, Zhiqiang Li, Jincao Chen, Lianrong Wang, Shi Chen
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Wiley 2024-11-01
Ráidu:	Advanced Science
Fáttát:	Alzheimer's disease endo‐lysosome network disorder energy metabolism hippocampus degeneration iron homeostasis SorL1
Liŋkkat:	https://doi.org/10.1002/advs.202407709
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