Endo‐Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1‐Null Rat Hippocampus

Abstract Sortilin‐related receptor 1 (SorL1) deficiency is a genetic predisposition to familial Alzheimer’s disease (AD), but its pathology is poorly understood. In SorL1‐null rats, a disorder of the global endosome‐lysosome network (ELN) is found in hippocampal neurons. Deletion of amyloid precurso...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Yajie Wang, Yuting Yang, Ying Cai, Ayikaimaier Aobulikasimu, Yuexin Wang, Chuanwei Hu, Zhikang Miao, Yue Shao, Mengna Zhao, Yue Hu, Chang Xu, Xinjun Chen, Zhiqiang Li, Jincao Chen, Lianrong Wang, Shi Chen
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2024-11-01
Sarja:	Advanced Science
Aiheet:	Alzheimer's disease endo‐lysosome network disorder energy metabolism hippocampus degeneration iron homeostasis SorL1
Linkit:	https://doi.org/10.1002/advs.202407709
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!