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Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease

Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to...

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Bibliografische Detailangaben
Hauptverfasser: Drew A. Gillett, Rebecca L. Wallings, Oihane Uriarte Huarte, Malú Gámez Tansey
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2023-11-01
Schriftenreihe:Journal of Neuroinflammation
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Online-Zugang:https://doi.org/10.1186/s12974-023-02965-w
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