Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic Lesions of Human Aortic Intima

Mitochondrial dysfunction and oxidative stress are likely involved in atherogenesis. Since the mitochondrial genome variation can alter functional activity of cells, it is necessary to assess the presence in atherosclerotic lesions of mitochondrial DNA (mtDNA) heteroplasmic mutations known to be ass...

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Autors principals:	Igor A. Sobenin, Andrey V. Zhelankin, Zukhra B. Khasanova, Vasily V. Sinyov, Lyudmila V. Medvedeva, Maria O. Sagaidak, Vsevolod J. Makeev, Kira I. Kolmychkova, Anna S. Smirnova, Vasily N. Sukhorukov, Anton Y. Postnov, Andrey V. Grechko, Alexander N. Orekhov
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2019-09-01
Col·lecció:	Biomolecules
Matèries:	atherosclerosis mitochondrial DNA mutations next generation sequencing mitochondrial DNA copy number unaffected intima fatty infiltration fatty streaks lipofibrous plaque fibrous plaque
Accés en línia:	https://www.mdpi.com/2218-273X/9/9/455
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