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Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic Lesions of Human Aortic Intima

Mitochondrial dysfunction and oxidative stress are likely involved in atherogenesis. Since the mitochondrial genome variation can alter functional activity of cells, it is necessary to assess the presence in atherosclerotic lesions of mitochondrial DNA (mtDNA) heteroplasmic mutations known to be ass...

Deskribapen osoa

Gorde:
Egile Nagusiak: Igor A. Sobenin, Andrey V. Zhelankin, Zukhra B. Khasanova, Vasily V. Sinyov, Lyudmila V. Medvedeva, Maria O. Sagaidak, Vsevolod J. Makeev, Kira I. Kolmychkova, Anna S. Smirnova, Vasily N. Sukhorukov, Anton Y. Postnov, Andrey V. Grechko, Alexander N. Orekhov
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI AG 2019-09-01
Saila:Biomolecules
Gaiak:
atherosclerosis
mitochondrial DNA mutations
next generation sequencing
mitochondrial DNA copy number
unaffected intima
fatty infiltration
fatty streaks
lipofibrous plaque
fibrous plaque
Sarrera elektronikoa:https://www.mdpi.com/2218-273X/9/9/455
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