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Mitochondrial Genome Editing: Exploring the Possible Relationship of the Atherosclerosis-Associated Mutation m.15059G>A With Defective Mitophagy

Objective The aim of this study was to evaluate the effect of the m.15059G>A mitochondrial nonsense mutation on cellular functions related to atherosclerosis, such as lipidosis, pro-inflammatory response, and mitophagy. Heteroplasmic mutations have been proposed as a potential cause of mitochondria...

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Autori principali: Vasily N. Sukhorukov, Victoria A. Khotina, Vladislav A. Kalmykov, Alexander D. Zhuravlev, Vasily V. Sinyov, Daniil Y. Popov, Andrey Y. Vinokurov, Igor A. Sobenin, Alexander N. Orekhov
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Korean Society of Lipid and Atherosclerosis 2024-05-01
Serie:Journal of Lipid and Atherosclerosis
Soggetti:
atherosclerosis
mitochondria
inflammation
lipid metabolism
mitophagy
Accesso online:https://www.e-jla.org/search.php?where=aview&id=10.12997/jla.2024.13.2.166&code=9992JLA&vmode=FULL
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