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PECAM-1 drives β-catenin-mediated EndMT via internalization in colon cancer with diabetes mellitus

Abstract Background Diabetes mellitus (DM) is considered to be a risk factor in carcinogenesis and progression, although the biological mechanisms are not well understood. Here we demonstrate that platelet-endothelial cell adhesion molecule 1 (PECAM-1) internalization drives β-catenin-mediated endot...

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Huvudupphov: Qing Wu, Xingxing Du, Jianing Cheng, Xiuying Qi, Huan Liu, Xiaohong Lv, Xieyang Gong, Changxin Shao, Muhong Wang, Luxiao Yue, Xin Yang, Shiyu Li, Yafang Zhang, Xuemei Li, Huike Yang
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2023-08-01
Serie:Cell Communication and Signaling
Ämnen:
Colon cancer
Diabetes mellitus
EndMT
PECAM-1
β-catenin
Länkar:https://doi.org/10.1186/s12964-023-01193-2
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