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Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway

Background: Cardiac remodeling is a common pathological feature in many cardiac diseases, characterized by cardiac hypertrophy and fibrosis. Triptolide (TP) is a natural compound derived from Tripterygium wilfordii Hook F. However, the related mechanism of it in cardiac remodeling has not been fully...

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Main Authors: Lina Ba, Mingyao E, Ruixuan Wang, Nan Wu, Rui Wang, Renling Liu, Xiang Feng, Hanping Qi, Hongli Sun, Guofen Qiao
Format: Artigo
Language:Inglês
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Triptolide
Cardiac remodeling
Cardiac hypertrophy
Cardiac fibrosis
Pyroptosis
EndMT
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024000410
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