One-Pot Phosphonylation of Heteroaromatic Lithium Reagents: The Scope and Limitations of Its Use for the Synthesis of Heteroaromatic Phosphonates

A one-pot lithiation–phosphonylation procedure was elaborated as a method to prepare heteroaromatic phosphonic acids. It relied on the direct lithiation of heteroaromatics followed by phosphonylation with diethyl chlorophosphite and then oxidation with hydrogen peroxide. This protocol provided the d...

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Detalhes bibliográficos

Principais autores:	Ewa Chmielewska, Natalia Miodowska, Błażej Dziuk, Mateusz Psurski, Paweł Kafarski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-03-01
coleção:	Molecules
Assuntos:	aminophosphonates heteroaromatic lithiation phosphonylation phosphonic acids organophosphorus chemistry
Acesso em linha:	https://www.mdpi.com/1420-3049/28/7/3135
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