Non-Canonical, Strongly Selective Protein Disulfide Isomerases as Anticancer Therapeutic Targets

Protein Disulfide Isomerases (PDIs) are emerging targets in anticancer therapy, with several PDI inhibitors demonstrating anticancer efficacy in preclinical models. Research has largely focused on “canonical” PDIs, such as PDIA1, which contain CXXC active site motifs where C represents Cysteine. Can...

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Autori principali:	Mary E. Law, Zaafir M. Dulloo, Brian Hardy, Ania Kelegama, Reagan Clark, Mariana Rivas Montbrun, Gabriella Antmann, Srihith Nooka, Ronald K. Castellano, Brian K. Law
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-08-01
Serie:	Biomolecules
Soggetti:	protein disulfide isomerases PDIA1 AGR2 AGR3 ERp44
Accesso online:	https://www.mdpi.com/2218-273X/15/8/1146
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