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Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy

The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy. We screened a library of Fas-TNFR proteins identifying several novel chimeras tha...

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Principais autores: Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew Robson, Katarina Lamb, Christopher Allen, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-06-01
Serier:Molecular Therapy: Nucleic Acids
Fag:
MT: Oligonucleotides: Therapies and Applications
apoptosis
Fas ligand
adoptive cell therapy
CAR T cells
synthetic biology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2162253123001038
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