Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy

The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy. We screened a library of Fas-TNFR proteins identifying several novel chimeras tha...

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Autores principales:	Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew Robson, Katarina Lamb, Christopher Allen, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2023-06-01
Colección:	Molecular Therapy: Nucleic Acids
Materias:	MT: Oligonucleotides: Therapies and Applications apoptosis Fas ligand adoptive cell therapy CAR T cells synthetic biology
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2162253123001038
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