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Immune checkpoint inhibitors in dMMR-MSI-H colorectal cancer: rationale, progress and prospects

Colorectal cancer (CRC) with a deficient mismatch repair and high microsatellite instability (dMMR–MSI-H) phenotype represents a biologically distinct subtype characterized by elevated tumor mutational burden and strong immunogenicity. These features contribute to their exceptional responsiveness to...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Guangre Xu, Die Liang, Lei Li, Jian Cheng, Xuejun Wang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2026-07-01
Rangatū:Frontiers in Immunology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1828717/full
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