Proteomic analysis reveals early pathological defects in corticospinal motor neurons of a spastin model of hereditary spastic paraplegia, which are improved by NU-9 treatment

Upper motor neuron (UMN) degeneration is a characteristic feature of hereditary spastic paraplegia (HSP), a genetically heterogeneous heritable neurodegenerative disorder resulting from mutations in over ninety genes. The mutations in the SPAST gene, which encodes the microtubule-severing protein sp...

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Detalhes bibliográficos

Principais autores:	Mukesh Gautam, Mercedes Priego, Christopher Quintanilla, Omar Kashow, Byoung-Kyu Cho, Young Ah Goo, Richard B. Silverman, Gerardo Morfini, Peter W. Baas, P. Hande Ozdinler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-09-01
coleção:	Neurobiology of Disease
Assuntos:	Spastin HSP CSMN Upper motor neurons NU-9
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996126002391
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