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Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens

Human metapneumovirus (HMPV) is a pneumovirus that may cause severe respiratory disease in humans. HMPV infection has been found to increase susceptibility to bacterial superinfections leading to increased morbidity and mortality. The molecular mechanisms underlying HMPV-mediated increase in bacteri...

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Principais autores: Simon Loevenich, Nicola P. Montaldo, Arthur Wickenhagen, Tatyana Sherstova, Barbara van Loon, Victor Boyartchuk, Marit W. Anthonsen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-06-01
coleção:Frontiers in Immunology
Assuntos:
human metapneumovirus
co-infection
airway bacteria
proinflammatory cytokines
inflammasome
IFN-β
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1173605/full
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