Human metapneumovirus infection of organoid-derived human bronchial epithelium represents cell tropism and cytopathology as observed in in vivo models

ABSTRACT Human metapneumovirus (HMPV), a member of the Pneumoviridae family, causes upper and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly been performed in monolayers of undifferentiated epithelial cells. In vivo studies in cynomolgus macaques and cotton rats...

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Detalhes bibliográficos

Principais autores:	Pau Ribó-Molina, Stefan van Nieuwkoop, Anna Z. Mykytyn, Peter van Run, Mart M. Lamers, Bart L. Haagmans, Ron A. M. Fouchier, Bernadette G. van den Hoogen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2024-02-01
coleção:	mSphere
Assuntos:	human metapneumovirus organoids primary cell cultures tropism cytopathology
Acesso em linha:	https://journals.asm.org/doi/10.1128/msphere.00743-23
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