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Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer’s Disease: In Vivo, In Vitro, Histopathological, and Docking Studies

<b>Background:</b> Alzheimer’s disease (AD) is largely linked with oxidative stress, the accumulation of amyloid-<i>β</i> plaques, and hyperphosphorylated <i>τ</i>-protein aggregation. Alterations in dopaminergic and serotonergic neurotransmission have also been implicated in various AD-related symp...

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Huvudupphov: Khulood H. Oudah, Mazin A. A. Najm, Triveena M. Ramsis, Maha A. Ebrahim, Nirvana A. Gohar, Karema Abu-Elfotuh, Ehsan Khedre Mohamed, Ahmed M. E. Hamdan, Amira M. Hamdan, Reema Almotairi, Shaimaa R. Abdelmohsen, Khaled Ragab Abdelhakim, Abdou Mohammed Ahmed Elsharkawy, Eman A. Fayed
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2025-08-01
Serie:Pharmaceuticals
Ämnen:
bicyclic
tricyclic
CNS
multi-target
histopathological examination
AChE
Länkar:https://www.mdpi.com/1424-8247/18/8/1214
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