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Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we applied a genome-wide CRISPR-Cas9 screening to identi...

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Kaydedildi:
Asıl Yazarlar: Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications Ltd 2019-11-01
Seri Bilgileri:eLife
Konular:
CRISPR screen
EGFR TKI resistance
GPCR signaling
RIC8A
YAP signaling
ARIH2-CUL5 complex
Online Erişim:https://elifesciences.org/articles/50223
Etiketler: Etiketle
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