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Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites

How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.

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Autori principali: Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2022-02-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-022-28567-3
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