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Trans-cyclooctene—a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs

Abstract Background Trans-cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand Diels–Alder reactions. Since their discovery as bioorthogonal reaction partners, novel TCO derivatives have been developed to improve their reactiv...

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Principais autores: Karuna Adhikari, Maarten Vanermen, Gustavo Da Silva, Tim Van den Wyngaert, Koen Augustyns, Filipe Elvas
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2024-06-01
Serier:EJNMMI Radiopharmacy and Chemistry
Fag:
Trans-cyclooctene
Bioorthogonal chemistry
Pretargeted imaging and therapy
In vivo ligation
Online adgang:https://doi.org/10.1186/s41181-024-00275-x
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