Cannabichromeorcin targets cathepsin L to alleviate oxidative stress–Driven airway inflammation in severe asthma

Background: Severe asthma (SA) is characterized by corticosteroid insensitivity, persistent airway inflammation, and excessive oxidative stress, underscoring an urgent unmet therapeutic need. Meroterpenoids derived from Rhododendron capitatum Maxim have demonstrated potent anti-inflammatory properti...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Junwen Huang, Ying Chen, Yi Deng, Dapeng Hu, Yaoxin Chen, Yuemao Li, Cancan Xie, Keke Fan, Bang Zhu, Zhaoqian Gong, Jie Yang, Shuyu Huang, Xiaoqian Peng, Xianru Peng, Bing Huang, Wenqu Zhao, Qingfeng Du, Haijin Zhao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-07-01
Schriftenreihe:	Redox Biology
Schlagworte:	Cannabichromeorcin Severe asthma Cathepsin L NETs Unfolded protein response Oxidative stress
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213231726002302
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