NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism
Abstract Cuproptosis is a recently discovered form of regulated cell death triggered by mitochondrial copper accumulation and proteotoxic stress. Here, we provide the first evidence that glutathione (GSH), a major non-protein thiol in cells, acts as a cuproptosis inhibitor in pancreatic ductal adeno...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Portfolio
2024-11-01
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| Schriftenreihe: | Scientific Reports |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1038/s41598-024-81317-x |
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