Rescuing TP53 from nonsense: novel triazoles for translational readthrough via optimized drug design

Abstract Nonsense mutations introduce premature termination codons (PTCs), leading to mRNA degradation and the production of truncated, non-functional proteins. These mutations account for approximately 10% of TP53 alterations, a key driver in over 50% human cancers. Effective therapeutic strategies...

詳細記述

書誌詳細

主要な著者:	Davide Ricci, Michele Menditto, Giulia Culletta, Marco Tutone, Carla Rizzo, Andrea Pace, Laura Lentini, Ivana Pibiri
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2026-04-01
シリーズ:	Scientific Reports
主題:	P53 Nonsense mutations Cancer Translational readthrough Computer aided drug design Triazoles
オンライン･アクセス:	https://doi.org/10.1038/s41598-026-48790-y
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!