Rescuing TP53 from nonsense: novel triazoles for translational readthrough via optimized drug design

Abstract Nonsense mutations introduce premature termination codons (PTCs), leading to mRNA degradation and the production of truncated, non-functional proteins. These mutations account for approximately 10% of TP53 alterations, a key driver in over 50% human cancers. Effective therapeutic strategies...

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Detalhes bibliográficos

Principais autores:	Davide Ricci, Michele Menditto, Giulia Culletta, Marco Tutone, Carla Rizzo, Andrea Pace, Laura Lentini, Ivana Pibiri
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-04-01
Colecção:	Scientific Reports
Assuntos:	P53 Nonsense mutations Cancer Translational readthrough Computer aided drug design Triazoles
Acesso em linha:	https://doi.org/10.1038/s41598-026-48790-y
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