IL-6 and PD-1 antibody blockade combination therapy regulate inflammation and T lymphocyte apoptosis in murine model of sepsis

Abstract Background Interleukin-6 (IL-6) plays a central role in sepsis-induced cytokine storm involving immune hyperactivation and early neutrophil activation. Programmed death protein-1 (PD-1) is associated with sepsis-induced immunosuppression and lymphocyte apoptosis. However, the effects of sim...

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Bibliografiska uppgifter

Huvudupphov:	Song I Lee, Na Young Kim, Chaeuk Chung, Dongil Park, Da Hyun Kang, Duk Ki Kim, Min-Kyung Yeo, Pureum Sun, Jeong Eun Lee
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-01-01
Serie:	BMC Immunology
Ämnen:	Activation, Lymphocyte Activation, Neutrophil Interleukin 6 Sepsis
Länkar:	https://doi.org/10.1186/s12865-024-00679-z
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