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Ulinastatin modulates TRPM4 expression and apoptosis to mitigate cognitive dysfunction in aged perioperative neurocognitive disorder rats

Abstract Perioperative neurocognitive disorder (PND) is a long-term perioperative complication that affects elderly surgical patients. As the aging population continues to grow, the prevention and treatment of PND have become important issues to address. Research has shown that ulinastatin significa...

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Autores principales: Xiaohui Xia, Jiayi Li, Mengmeng Zhang, Chunyan Zhang, Keliang Lu, Huirong han
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2025-05-01
Colección:Scientific Reports
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Acceso en línea:https://doi.org/10.1038/s41598-025-01394-4
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