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APOE4 Exerts Partial Diet-dependent Effects on Energy Expenditure and Skeletal Muscle Mitochondrial Pathways in a Preclinical Model

Abstract Apolipoprotein E4 (APOE4) is the greatest genetic risk factor for Alzheimer's (AD) and is linked to whole-body metabolic dysfunction. However, it is unclear how APOE4 interacts with modifiable factors like diet to impact tissues central to regulating whole-body metabolism. We examined APOE4...

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Principais autores: Chelsea N Johnson, Colton R Lysaker, Elaine C Gast, Colin S McCoin, Riley E Kemna, Kelly N Z Fuller, Benjamin A Kugler, Edziu Franczak, Vivien Csikos, Julie Allen, Casey S John, MaryJane A Wolf, Matthew E Morris, John P Thyfault, Heather M Wilkins, Paige C Geiger, Jill K Morris
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2025-01-01
Serier:Function
Fag:
APOE4
Alzheimer's
mice
whole-body metabolism
skeletal muscle
proteomics
Online adgang:https://journals.physiology.org/doi/10.1093/function/zqaf017
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