CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model

Abstract Background Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule. Method We examined how intra-tumoral adenosine levels modify anti-tumor effects of RT in a murin...

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Autors principals:	Hidenori Tsukui, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Yasunaru Sakuma, Yoshinori Hosoya, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2020-05-01
Col·lecció:	BMC Cancer
Matèries:	Abscopal effect Adenosine CD73 Radiation Rectal cancer
Accés en línia:	http://link.springer.com/article/10.1186/s12885-020-06893-3
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