Development of New Pyrazolo [3,4-<i>b</i>]Pyridine Derivatives as Potent Anti-Leukemic Agents and Topoisomerase IIα Inhibitors with Broad-Spectrum Cytotoxicity

<b>Background/Objectives:</b> In the current medical era, Topoisomerase II is recognized as an essential enzyme that regulates DNA topology during critical biological processes such as DNA replication, transcription, and repair. This study aimed to design, synthesize, and biologically evaluate a new...

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Bibliografiske detaljer

Principais autores:	Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Veronika Vojáčková, Ahmed T. Negmeldin, Zainab M. Elsayed, Taghreed A. Majrashi, Petra Krňávková, Mostafa M. Elbadawi, Moataz A. Shaldam, Ghada H. Al-Ansary, Vladimír Kryštof, Hatem A. Abdel-Aziz
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2025-11-01
Serier:	Pharmaceuticals
Fag:	TOPIIα molecular modeling Western blotting apoptosis pyrazolopyridine
Online adgang:	https://www.mdpi.com/1424-8247/18/11/1770
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