Development of New Pyrazolo [3,4-<i>b</i>]Pyridine Derivatives as Potent Anti-Leukemic Agents and Topoisomerase IIα Inhibitors with Broad-Spectrum Cytotoxicity

<b>Background/Objectives:</b> In the current medical era, Topoisomerase II is recognized as an essential enzyme that regulates DNA topology during critical biological processes such as DNA replication, transcription, and repair. This study aimed to design, synthesize, and biologically evaluate a new...

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Bibliografski detalji

Glavni autori:	Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Veronika Vojáčková, Ahmed T. Negmeldin, Zainab M. Elsayed, Taghreed A. Majrashi, Petra Krňávková, Mostafa M. Elbadawi, Moataz A. Shaldam, Ghada H. Al-Ansary, Vladimír Kryštof, Hatem A. Abdel-Aziz
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2025-11-01
Serija:	Pharmaceuticals
Teme:	TOPIIα molecular modeling Western blotting apoptosis pyrazolopyridine
Online pristup:	https://www.mdpi.com/1424-8247/18/11/1770
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