Development of New Pyrazolo [3,4-<i>b</i>]Pyridine Derivatives as Potent Anti-Leukemic Agents and Topoisomerase IIα Inhibitors with Broad-Spectrum Cytotoxicity

<b>Background/Objectives:</b> In the current medical era, Topoisomerase II is recognized as an essential enzyme that regulates DNA topology during critical biological processes such as DNA replication, transcription, and repair. This study aimed to design, synthesize, and biologically evaluate a new...

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Үндсэн зохиолчид:	Wagdy M. Eldehna, Haytham O. Tawfik, Denisa Veselá, Veronika Vojáčková, Ahmed T. Negmeldin, Zainab M. Elsayed, Taghreed A. Majrashi, Petra Krňávková, Mostafa M. Elbadawi, Moataz A. Shaldam, Ghada H. Al-Ansary, Vladimír Kryštof, Hatem A. Abdel-Aziz
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2025-11-01
Цуврал:	Pharmaceuticals
Нөхцлүүд:	TOPIIα molecular modeling Western blotting apoptosis pyrazolopyridine
Онлайн хандалт:	https://www.mdpi.com/1424-8247/18/11/1770
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!