Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonucleotides (AONs) modified with bridged nucleic acid...

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Detalles Bibliográficos

Principais autores:	Tsuyoshi Yamamoto, Mariko Harada-Shiba, Moeka Nakatani, Shunsuke Wada, Hidenori Yasuhara, Keisuke Narukawa, Kiyomi Sasaki, Masa-Aki Shibata, Hidetaka Torigoe, Tetsuji Yamaoka, Takeshi Imanishi, Satoshi Obika
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2012-01-01
Series:	Molecular Therapy: Nucleic Acids
Assuntos:	antisense BNA hypercholesterolemia LNA PCSK9
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2162253116300816
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