Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonucleotides (AONs) modified with bridged nucleic acid...

Descripció completa

Dades bibliogràfiques

Autors principals:	Tsuyoshi Yamamoto, Mariko Harada-Shiba, Moeka Nakatani, Shunsuke Wada, Hidenori Yasuhara, Keisuke Narukawa, Kiyomi Sasaki, Masa-Aki Shibata, Hidetaka Torigoe, Tetsuji Yamaoka, Takeshi Imanishi, Satoshi Obika
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2012-01-01
Col·lecció:	Molecular Therapy: Nucleic Acids
Matèries:	antisense BNA hypercholesterolemia LNA PCSK9
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2162253116300816
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!