PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal.

Interferon-alpha (IFN) induces complete cytogenetic remission (CCR) in 20-25% CML patients and in a small minority of patients; CCR persists after IFN is stopped. IFN induces CCR in part by increasing cytotoxic T lymphocytes (CTL) specific for PR1, the HLA-A2-restricted 9-mer peptide from proteinase...

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Autors principals:	Shreya Kanodia, Eric Wieder, Sijie Lu, Moshe Talpaz, Gheath Alatrash, Karen Clise-Dwyer, Jeffrey J Molldrem
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2010-07-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC2909896?pdf=render
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