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PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal.

Interferon-alpha (IFN) induces complete cytogenetic remission (CCR) in 20-25% CML patients and in a small minority of patients; CCR persists after IFN is stopped. IFN induces CCR in part by increasing cytotoxic T lymphocytes (CTL) specific for PR1, the HLA-A2-restricted 9-mer peptide from proteinase...

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Principais autores: Shreya Kanodia, Eric Wieder, Sijie Lu, Moshe Talpaz, Gheath Alatrash, Karen Clise-Dwyer, Jeffrey J Molldrem
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2010-07-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2909896?pdf=render
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