A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea

Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), plays a critical role in the pathogenesis of OSA-associated morbidities, especially in the cardiovascular and respiratory systems. Oxidative stress and inflammation induced by IH are suggested as main contributors of end-organ d...

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Bibliografische Detailangaben

Hauptverfasser:	Noelia Campillo, Ignasi Jorba, Laura Schaedel, Blai Casals, David Gozal, Ramon Farre, Isaac Almendros, Daniel Navajas
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2016-07-01
Schriftenreihe:	Frontiers in Physiology
Schlagworte:	obstructive sleep apnea intermittent hypoxia hypoxia-inducible factor lab-on-a-chip cell stretch
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00319/full
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