Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea

Background: Patients with obstructive sleep apnea (OSA) experience recurrent hypoxemic events with a frequency sometimes exceeding 60 events/h. These episodic events induce downstream transient hypoxia in the parenchymal tissue of all organs, thereby eliciting the pathological consequences of OSA. W...

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Hlavní autoři:	Alicia Jurado, Anna Ulldemolins, Helena Lluís, Xavier Gasull, Núria Gavara, Raimon Sunyer, Jorge Otero, David Gozal, Isaac Almendros, Ramon Farré
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-01-01
Edice:	Frontiers in Pharmacology
Témata:	obstructive sleep apnea hypoxia cell culture hydrogels tissue slice 3D culture
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1081345/full
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