Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism

Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), by inducing the production of immunomodulatory molecules, e.g., IL-10. In an effort to find the upst...

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Autors principals:	Yao-Juan Chu, Wen-Di Ma, Rodolfo Thome, Jie-Dan Ping, Fang-Zhou Liu, Meng-Ru Wang, Ming-Liang Zhang, Guangxian Zhang, Lin Zhu
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-09-01
Col·lecció:	Frontiers in Immunology
Matèries:	matrine multiple sclerosis experimental autoimmune encephalomyelitis IFN-β IL-10 IL-27
Accés en línia:	https://www.frontiersin.org/article/10.3389/fimmu.2020.569530/full
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