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Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism

Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), by inducing the production of immunomodulatory molecules, e.g., IL-10. In an effort to find the upst...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Yao-Juan Chu, Wen-Di Ma, Rodolfo Thome, Jie-Dan Ping, Fang-Zhou Liu, Meng-Ru Wang, Ming-Liang Zhang, Guangxian Zhang, Lin Zhu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-09-01
Schriftenreihe:Frontiers in Immunology
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Online-Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2020.569530/full
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