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Increased IL-2 and Reduced TGF-β Upon T-Cell Stimulation are Associated with GM-CSF Upregulation in Multiple Immune Cell Types in Multiple Sclerosis

Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. We investigated the expression and regulation of GM-CSF in different immune cells i...

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Principais autores: Jehan Aram, Nanci Frakich, Elena Morandi, Mohammed Alrouji, Amal Samaraweera, David Onion, Ian Spendlove, Sergio L. Colombo, Radu Tanasescu, Bruno Gran, Cris S. Constantinescu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-07-01
Serier:Biomedicines
Fag:
GM-CSF
human
MS/EAE
PBMC
T cells
B cells
Online adgang:https://www.mdpi.com/2227-9059/8/7/226
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