Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Abstract Background There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phospho-Akt in PDAC tissues and cells, and investigated molecular mechanisms...

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Detalhes bibliográficos

Principais autores:	Daniela Massihnia, Amir Avan, Niccola Funel, Mina Maftouh, Anne van Krieken, Carlotta Granchi, Rajiv Raktoe, Ugo Boggi, Babette Aicher, Filippo Minutolo, Antonio Russo, Leticia G. Leon, Godefridus J. Peters, Elisa Giovannetti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-01-01
Colecção:	Journal of Hematology & Oncology
Assuntos:	Pancreatic ductal adenocarcinoma Akt Synergism Gemcitabine
Acesso em linha:	http://link.springer.com/article/10.1186/s13045-016-0371-1
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