Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Abstract Background There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phospho-Akt in PDAC tissues and cells, and investigated molecular mechanisms...

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Auteurs principaux:	Daniela Massihnia, Amir Avan, Niccola Funel, Mina Maftouh, Anne van Krieken, Carlotta Granchi, Rajiv Raktoe, Ugo Boggi, Babette Aicher, Filippo Minutolo, Antonio Russo, Leticia G. Leon, Godefridus J. Peters, Elisa Giovannetti
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2017-01-01
Collection:	Journal of Hematology & Oncology
Sujets:	Pancreatic ductal adenocarcinoma Akt Synergism Gemcitabine
Accès en ligne:	http://link.springer.com/article/10.1186/s13045-016-0371-1
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