Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer
Abstract Background There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phospho-Akt in PDAC tissues and cells, and investigated molecular mechanisms...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , , , , , , , , , , , , |
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| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
BMC
2017-01-01
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| মালা: | Journal of Hematology & Oncology |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | http://link.springer.com/article/10.1186/s13045-016-0371-1 |
| ট্যাগগুলো: |
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